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PARP1 Parylation Promotes Silent Locus Transmission in the Nucleolus: The Suspicion Confirmed
Journal article   Open access  Peer reviewed

PARP1 Parylation Promotes Silent Locus Transmission in the Nucleolus: The Suspicion Confirmed

Maxim Isabelle, Imed-Eddine Gallouzi and Guy G. Poirier
Molecular cell, Vol.45(6), pp.706-707
30/03/2012
DOI: https://doi.org/10.1016/j.molcel.2012.03.012
PMID: 22464439

Abstract

Biochemistry & Molecular Biology Cell Biology Life Sciences & Biomedicine Science & Technology
Parylation modulates various processes, including transcription. In this issue of Molecular Cell, Guetg et al. (2012) show that, in the nucleolus, PARP1-mediated parylation of TIP5 promotes the silencing of rDNA chromatin during replication, uncovering the mechanism by which PARP1 ensures that silent rDNA regions are properly inherited.
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https://doi.org/10.1016/j.molcel.2012.03.012View
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