Abstract
A facile and effective synthesis of reported some new series of ((Z)-2-((5-(4-fluorobenzylidene)-4-oxo-4, 5-dihydrothiazol-2-yl)amino)-substituted acid in polyethylene glycol under conventional and microwave irradiation method. Nucleophilic Ipso-substitution between amino acid and methylthio-thiazolone was successfully carried out with good yield in less time of reaction using microwave irradiation method.