Abstract
Camels are one of the most sensitive animals to E. coli endotoxin and their pathophysiological effects on the body. In this work, pharmacokinetics of danofloxacin was studied in normal and febrile camels after single intravenous (i.v.) and intramuscular (i.m.) administration of 1.25 mg kg(-1). Plasma concentrations of the drug were determined by high performance liquid chromatography (HPLC). Following i.v. administration plasma danofloxacin curves were declined bi-physically in normal and febrile camels that characterised two compartment open model. The distribution pattern (t(1/2 alpha) and V-dss) of the drug was not altered by endotoxaemia. Danofloxacin was rapidly cleared from febrile camels, total body clearance CLB, 0.16 l h(-1) kg(-1) versus 0.31 l h(-1) kg(-1) in normal camels. Plasma concentrations of danofloxacin, AUC and elimination half life (t(1/2 beta)) following both routes were significantly higher in febrile camels than in normal ones. Fever significantly increased the MAT and absorption half-life of danofloxacin but did not alter the systemic bioavailability.