Abstract
Biosynthesis of silver nanoparticles (AgNPs) by vegetal extracts is useful because of their biocompatibility, less harmfulness, and environmental friendly nature. This research work focuses on AgNPs synthesis through an ethanol extract of Cinnamomum camphora leaves. Characterization of AgNPs was performed using ultraviolet-visible spectroscopy, scanning electron microscopy, and functional groups acquired by this process were analyzed through Fourier- Transform Infrared Radiation (FTIR) spectroscopy. The impacts of C. camphora plant extract (CcExt)) and the extract with silver nanoparticles (CcExt-AgNPs) were examined for mosquitoe (Culex pipiens) larvicidal efficacy and various biological activities including splenic cell cytotoxicity/proliferation, acute cytotoxicity on hepatic cells, hemolysis, and antibacterial activities. Both CcExt and CcExt-AgNPs revealed a substantial larvicidal effect against fourth instar larvae of the mosquitoe and a significant antibacterial activity. Furthermore, a significant effects of CcExt and CcExt-AgNPs were observed on normal splenic cells cytotoxicity/proliferation, hepatic cells acute cytotoxicity, and hemolytic percentage. Formation of AgNPs was confirmed by all applied characterization methods. CcExt and CcExt-AgNPs had potential biological activities. Current studies revealed that C. camphora leaves extract was safe to vital organs (liver) while the treatment with AgNPs showed a little non-significant increase in liver function markers.