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PPL-catalysed hydrolysis of 3,4-disubstituted β-lactams: Effect of chain length and stereochemistry on the enantioselectivity
Journal article   Peer reviewed

PPL-catalysed hydrolysis of 3,4-disubstituted β-lactams: Effect of chain length and stereochemistry on the enantioselectivity

Amit Basak, Gautam Bhattacharya and Hussam M.M Bdour
Tetrahedron, Vol.54(23), pp.6529-6538
04/06/1998
DOI: https://doi.org/10.1016/S0040-4020(98)00313-5

Abstract

3,4-Disubstituted β-lactam acetates 1a–15a have been subjected to PPL-catalysed hydrolysis. The stereochemical course of hydrolysis has been shown to depend upon the C3–C4 relative stereochemistry and the length of the chain bearing acetate functionality. Graphic

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