Abstract
An acetyl salicylic acid-valine complex was prepared and evaluated for the potential transdermal application. The complex prepared by freeze-drying technique. The complex was analyzed by using differential scanning calorimetry (DSC), scanning electron microscope (SEM), H-1 nuclear magnetic resonance (H-1 NMR), X-ray powder diffraction (X-RPD) and Fourier transform infrared (FTIR). The results revealed the formation of an ionic type complex between acetyl salicylic acid and valine in a molar ratio of 1:1. This study comprised formulation of the complex in different gel bases. Release studies revealed that the 7% w/w sodium alginate gel allowed highest complex release and 20% w/w pluronic F-127 showed the lowest release. Permeation studies through rat skin revealed that 0.5% w/w carpobol 934 showed the highest flux from all studies gel bases and high complex permeation compared to acetyl salicylic acid alone. The present results confirmed that acetyl salicylic acid-valine complex is a promising and safe delivery system that can be utilized for transdermal application.