Abstract
Acute kidney injury is a common and life-threatening complication of sepsis. It is known to be associated with at least 50% mortality. Therefore, understanding the pathogenesis and prevention of sepsis-induced acute kidney injury has been a subject of concern for may decades. Although the details of the basic mechanisms of the condition remain elusive, some processes were discovered, and many advances were made. Sepsis-induced acute kidney injury occurs due to complex mechanisms that act synergistically to damage renal tissue. The main revealed mechanisms are microcirculatory dysfunction, systemic inflammation, and local maladaptive response of the renal tissue. Prevention of acute kidney injury among patients with sepsis necessitates targeting these mechanisms. This article aims at discussing the pathogenesis and preventive measures of sepsis-induced acute kidney injury.