Abstract
The action of fresh minced garlic and garlic oil on aflatoxin B-1- (AFB(1)) induced carcinogenesis in the toad Bufo regularis was studied. Feeding roads with AFB(1) induced tumors in 19% of the animals. Animals given AFB(1) together with fresh garlic or garlic oil showed a significant reduction in tumor incidence. The tumor incidences were 3% and 9% in animals given AFB(1) plus garlic and AFB(1) plus garlic oil, respectively. In all three groups, the tumors were located in the liver (hepatocellular carcinomas), in addition to the kidney in animals treated with AFB(1) alone and together with garlic. The kidney tumors were diagnosed as metastatic deposits from the primary liver tumors. It is speculated that one or more constituents of garlic may be responsible for inhibition of AFB(1)-induced carcinogenesis in B. regularis.