Abstract
Inflammatory bowel disease is an idiopathic, immune mediated and chronic inflammatory condition of intestine. The objective of the present study was to elucidate the protective effect of aqueous extract of fruits of Garcinia pedunculata (AEGP) in acetic acid induced ulcerative colitis in Swiss albino mice. The mice were grouped into four different categories each with six mice. The acetic acid induced colitis was assessed by measuring macroscopic damage score as well as biochemical and histological changes in colon tissue after 7 days of treatment regimen. Administration of AEGP at 400mg/kg exhibited significant effect in lowering acetic acid induced macroscopic damage score, lipid peroxidation and histopathalogical changes in colon tissue. The results suggest that the aqueous extracts of fruits of Garcinia pedunculata have ameliorating effect on experimental colitis by enhancing cytoprotective activity.