Abstract
The goal of this research was to explore the underlying hepatoprotective mechanisms of Omega-3 fatty acids against liver toxicity in response to cadmium chloride exposure (Cd) in rats. Cd (5 mg /kg b.w) was ingested to rats daily for 6 days. Omega-3 fatty acids (100 mg/kg b.w.) were ingested orally to Cd intoxicated rats simultaneously with or before Cd intoxication daily for 6 days. Data revealed that administration of Omega-3 fatty acids simultaneously with or before Cd intoxication, significantly diminished the increases in hepatic malondialdehyde (MDA) and ameliorated the depletion in antioxidant enzymes, namely superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transfrease (GST). The fatty acids also attenuated the increase in hepatic 8-hydroxy-2'-deoxyguanosine (8-OHdG, index of DNA damage), interferon gamma (IFN gamma), nuclear factor kappa B (NF-kappa B) and heat shock protein-70KDs (HSP-70). The existing biochemical investigations were confirmed by histo-cytologic observation. Conclusion: the present investigation propose that the hepatoprotective impacts of Omega-3 fatty acids against Cd caused liver toxicity in rats may ascribe to their anti-oxidative stress, antioxidant and anti-inflammatory beneficial actions. Copyright (c) 2013 - All Rights Reserved - Pharmacophore