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Palladium-Catalyzed Synthesis of Substituted Pyrido[2,3-d]pyridazines at Positions 5 and 8
Journal article   Peer reviewed

Palladium-Catalyzed Synthesis of Substituted Pyrido[2,3-d]pyridazines at Positions 5 and 8

Mohamed A. Ibrahim, Emilie Blaise, Olivier Lozach, Claude Szalata, Martine Schmitt, Abd-Allah S. El-Etrawy, Mohamed Elagawany, Said A. El-Feky, Zakraia K. Abdel-Samii, Laurent Meijer, …
Synthesis (Stuttgart), Vol.44(20), pp.3216-3224
18/10/2012
DOI: https://doi.org/10.1055/s-0032-1317145

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Several synthetic strategies were developed for the preparation of highly substituted pyrido[2,3-d]pyridazines. We particularly focused on the impact of the pyridine nitrogen atom on pyridazine ring reactivity toward aromatic substitutions, alkylations, or pallado-catalyzed cross-coupling reactions.

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