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Parallel kinetic resolution of racemic 1-phenylethanol using quasi-enantiomeric combinations of carboxylic acids mediated by N,N '-dicyclohexylcarbodiimide and 3,5-lutidine
Journal article   Peer reviewed

Parallel kinetic resolution of racemic 1-phenylethanol using quasi-enantiomeric combinations of carboxylic acids mediated by N,N '-dicyclohexylcarbodiimide and 3,5-lutidine

Najla Al Shaye, Andrew N. Boa, Elliot Coulbeck and Jason Eames
Tetrahedron letters, Vol.49(31), pp.4661-4665
28/07/2008
DOI: https://doi.org/10.1016/j.tetlet.2008.05.036

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
The parallel kinetic resolution of racemic 1-phenylethanol using an equimolar combination of quasienantiomeric 2-arylpropionic and butanoic acids mediated by a N,N'-dicyclohexylcarbodiimide (DCC)/3,5-lutidine coupling is discussed. The levels of diastereoselectivity were high leading to separable quasi-enantiomeric esters in good yield. (C) 2008 Elsevier Ltd. All rights reserved.

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