Parameters for reliable results in genetic association studies in common disease

John A Todd; Ingrid Dahlman; Iain A Eaves; Roman Kosoy; V. Anne Morrison; Joanne Heward; Stephen C.L Gough; Amit Allahabadia; Jayne A Franklyn; Jaakko Tuomilehto; Eva Tuomilehto-Wolf; Francesco Cucca; Cristian Guja; Constantin Ionescu-Tirgoviste; Helen Stevens; Philippa Carr; Sarah Nutland; Patricia McKinney; Julian P Shield; William Wang; Heather J Cordell; Neil Walker; Patrick Concannon; J. Tuomilehto

doi:10.1038/ng825

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Parameters for reliable results in genetic association studies in common disease

Journal article

Peer reviewed

Parameters for reliable results in genetic association studies in common disease

John A Todd, Ingrid Dahlman, Iain A Eaves, Roman Kosoy, V. Anne Morrison, Joanne Heward, Stephen C.L Gough, Amit Allahabadia, Jayne A Franklyn, Jaakko Tuomilehto, …

Nature genetics, Vol.30(2), pp.149-150

01/02/2002

DOI: https://doi.org/10.1038/ng825

PMID: 11799396

Abstract

It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands rather than the hundreds of individuals employed to date. Using 2,873 families, we were unable to confirm a recently published association of the interleukin 12B gene in 422 type I diabetic families. These results emphasize the need for large datasets, small P values and independent replication if results are to be reliable.

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Title: Parameters for reliable results in genetic association studies in common disease
Creators - without role: John A Todd - University of Cambridge
Ingrid Dahlman - University of Cambridge
Iain A Eaves - University of Cambridge
Roman Kosoy - Virginia Mason Medical Center
V. Anne Morrison - Virginia Mason Medical Center
Joanne Heward - University of Birmingham
Stephen C.L Gough - Queen Elizabeth Hospital Birmingham
Amit Allahabadia - Queen Elizabeth Hospital Birmingham
Jayne A Franklyn - University of Birmingham
Jaakko Tuomilehto - University of Helsinki
Eva Tuomilehto-Wolf - Institute for Molecular Medicine Finland
Francesco Cucca - University of Cagliari
Cristian Guja - Clinic of Diabetes, Institute of Diabetes, Nutrition and Metabolic Diseases "N. Paulescu"
Constantin Ionescu-Tirgoviste - Clinic of Diabetes, Institute of Diabetes, Nutrition and Metabolic Diseases "N. Paulescu"
Helen Stevens - Wellcome Trust
Philippa Carr - University of Cambridge
Sarah Nutland - Wellcome Trust
Patricia McKinney - Paediatric Epidemiology Group, Unit of Epidemiology and HSR
Julian P Shield - University of Bristol
William Wang - University of Cambridge
Heather J Cordell - University of Cambridge
Neil Walker - Wellcome Trust
Patrick Concannon - Virginia Mason Medical Center
J. Tuomilehto - King Abdulaziz University
Publication Details: Nature genetics, Vol.30(2), pp.149-150
Identifiers: 9937163408331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article