Abstract
The nonlinear confusion component is one of an integral part of any modern block cipher. This nonlinear confusion component is used to hides the relationship between the ciphertext and the key. The primary objective of this article is to formulate a new mechanism for the construction this confusion component. Usually substitution box (S-box) is used to achieve this kind of characteristics in block ciphers. We have utilized deoxyribonucleic acid (DNA) sequences for the construction of new S-boxes with optimized cryptographic characteristics. The projected technique fundamentally optimized the DNA sequences along with traditional confusion component to generate a completely new S-box. The obtained S-boxes have the same cryptographic strength as a parent S-box have.