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Pd-free Sonogashira coupling: one pot synthesis of phthalide via domino Sonogashira coupling and 5-exo-dig cyclization
Journal article   Peer reviewed

Pd-free Sonogashira coupling: one pot synthesis of phthalide via domino Sonogashira coupling and 5-exo-dig cyclization

Shubhendu Dhara, Raju Singha, Munmun Ghosh, Atiur Ahmed, Yasin Nuree, Anuvab Das and Jayanta K. Ray
RSC advances, Vol.4(80), pp.42604-42607
01/01/2014
DOI: https://doi.org/10.1039/c4ra07639g

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
Phthalides have been synthesized exclusively in one pot via Pd-free Sonogashira coupling. A Cu-catalyzed domino Sonogashira coupling and 5-exo-dig cyclization between suitable substituted ortho-bromobenzoic acids and terminal alkynes afforded phthalides in good yields under mild reaction conditions.

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