Abstract
Pemphigus foliaceus (PF) is a rare form of pemphigus disease (PD). PD is a chronic autoimmune blistering skin disease. Here we report a case of a 65-year-old female who presented with a 2 months history of persistent slowly progressing painful skin lesions on her face. Skin examination revealed non-scaly, erythematous patches on her face with a butterfly rash distribution. Skin biopsy revealed subcorneal blister with presence of acantholytic keratinocytes in the blister cavity. Intracellular deposition of IgG and C3 in the epidermis was demonstrated using direct immune fluorescence (DIF). Complete blood counts, ESR, blood urea, creatinine, liver function tests, urine examination, ANA, ant d DNA, anti-smith antibodies were all within normal limits. Patient was diagnosed as Pemphigus foliaceus. We started her treatment using prednisolone 20 mg once per day. The lesions disappeared within few weeks of starting the treatment.