Abstract
The pharmacokinetics of long-acting Oxytetracycline (OTC) formulation (Alamycin-LA) was studied after intramuscular (IM) route at a dose of 1 mg kg(-1) body weight to fifteen healthy desert sheep. The mean C-max values of 74.8 +/- 13.22 mu g mL(-1) was after 0.9 +/- 0.13 h, the mean distribution phase was 2.0 +/- 0.4 h and the apparent elimination half-life was 126 23 h. The volume of distribution (V-d) was found to be 67.933 +/- 4.88 L. The area under the curve (AUC(240)(0)) and the area under concentration-time curve (AUMC) were 2530.26 +/- 203.3, 242522.2 +/- 48504.5 mu g/ml/h(2), respectively. The total body clearance (cl(beta)) was 373.63 +/- 18,9 mL h(-1) while the mean resident time (MRT) was 90.61 +/- 13.8 h.