Abstract
Phenoxyacetohydrazide Schiff base analogs 1-28 have been synthesized and their in vitro beta-glucouoronidase inhibition potential studied. Compounds 1 (IC50 = 9.20 +/- 0.32 mu M), 5 (IC50 = 9.47 +/- 0.16 mu M), 7 (IC50 = 14.7 +/- 0.19 mu M), 8 (IC50 = 15.4 +/- 1.56 mu M), 11 (IC50 = 19.6 +/- 0.62 mu M), 12 (IC50 = 30.7 +/- 1.49 mu M), 15 (IC50 = 12.0 +/- 0.16 mu M), 21 (IC50 = 13.7 +/- 0.40 mu M) and 22 (IC50 = 22.0 +/- 0.14 mu M) showed promising beta-glucuronidase inhibition activity, better than the standard (D-saccharic acid-1,4-lactone, IC50 = 48.4 +/- 1.25 mu M).