Phenylpropanoid NF-κB inhibitors from Bupleurum fruticosum

P. Bremner; S. Tang; H. Birkmayer; B. L. Fiebich; E. Muñoz; N. Marquez; D. Rivera; M. Heinrich

doi:10.1055/s-2004-832616

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Phenylpropanoid NF-κB inhibitors from Bupleurum fruticosum

Journal article

Peer reviewed

Phenylpropanoid NF-κB inhibitors from Bupleurum fruticosum

P. Bremner, S. Tang, H. Birkmayer, B. L. Fiebich, E. Muñoz, N. Marquez, D. Rivera and M. Heinrich

Planta medica, Vol.70(10), pp.914-918

10/2004

DOI: https://doi.org/10.1055/s-2004-832616

Abstract

Original Paper

Abstract Two phenylpropanoids from BUPLEURUM FRUTICOSUM (Apiaceae/Umbelliferae) were shown to inhibit the transcriptional activity induced by PMA or TNFα of an NF-κB-controlled reporter gene. Western blot experiments indicated that the phenylpropanoids did not prevent IκBα degradation, suggesting that their molecular target is at a post-IKB degradation level. Both compounds prevented cytokine (IL-1, IL-6, TNF, IL-8) release and prostaglandin E 2 synthesis.

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Title: Phenylpropanoid NF-κB inhibitors from Bupleurum fruticosum
Creators - without role: P. Bremner - The Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, London, UK
S. Tang - The Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, London, UK
H. Birkmayer - The Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, London, UK
B. L. Fiebich - University of Freiburg
E. Muñoz - Department of Cellular Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
N. Marquez - Department of Cellular Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
D. Rivera - Universidad de Murcia
M. Heinrich - The Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, London, UK
Publication Details: Planta medica, Vol.70(10), pp.914-918
Identifiers: 9937942108331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article