Photochemical and DNA degradation studies on tenoxicam, lornoxicam, and their photolysis products

Ibrahim Elghamry; Usama El-Ayaan; Magdy M. Youssef; Shar Al-Shihry; Matthias Letzel; Jochen Mattay

doi:10.1007/s00706-016-1765-z

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Photochemical and DNA degradation studies on tenoxicam, lornoxicam, and their photolysis products

Journal article

Peer reviewed

Photochemical and DNA degradation studies on tenoxicam, lornoxicam, and their photolysis products

Ibrahim Elghamry, Usama El-Ayaan, Magdy M. Youssef, Shar Al-Shihry, Matthias Letzel and Jochen Mattay

Monatshefte für Chemie, Vol.148(2), pp.257-262

01/02/2017

DOI: https://doi.org/10.1007/s00706-016-1765-z

Abstract

Analytical Chemistry

Chemistry

Chemistry and Materials Science

Chemistry/Food Science

general

Inorganic Chemistry

Organic Chemistry

Original Paper

Physical Chemistry

Theoretical and Computational Chemistry

Tenoxicam and lornoxicam are nonsteroidal anti-inflammatory drugs, were subjected to photoirradiation at 254 nm led to the photodegradation of the pharmaceutical agents. Both, the isolated photodegradation products and the pharmaceutical agents were examined toward DNA binding and degradation. The photodegradation products degrade calf thymus in concentration dependent manner. Graphical abstract

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Title: Photochemical and DNA degradation studies on tenoxicam, lornoxicam, and their photolysis products
Creators - without role: Ibrahim Elghamry - King Faisal University
Usama El-Ayaan - King Faisal University
Magdy M. Youssef - King Faisal University
Shar Al-Shihry - King Faisal University
Matthias Letzel - University of Münster
Jochen Mattay - Bielefeld University
Publication Details: Monatshefte für Chemie, Vol.148(2), pp.257-262
Publisher: Springer Vienna
Grant note: 160025 / Deanship of Scientific Research, King Faisal University (http://dx.doi.org/10.13039/501100004686)
Identifiers: 9919455008331
Academic Unit: King Faisal University
Language: English
Resource Type: Journal article