Abstract
•Altering nanofibrous structures to be used for wound healing applications is crucially needed to improve quality of life.•Co-substituted hydroxyapatite (HAP) with different iron (Fe)/vanadate ions contributions are involved in polycaprolactone nanofiber.•The surface morphology for powdered Fe/V-HAP@PCL shows changes in grains size from 1.59–6.26 µm to 2.0–3.76 for the minimum and maximum Fe composition.•Mechanical parameters vary upon increasing dopant ions in HAP; tensile strength rises from 1.61 ± 0.8 to 4.93 ± 0.8 MPa.•Modulating the nanofibrous scaffold by controlling the composition of doped metal ions could be advantageous for biomedical applications.
Altering nanofibrous structures to be used for wound healing applications is crucially needed to improve quality of life. Co-substituted hydroxyapatite (HAP) with different iron (Fe)/vanadate (VO43−) ions contributions are involved in polycaprolactone (PCL), where the electrospinning method is used to fabricate PCL polymer. XRD explains both powder and nanofibrous scaffold structural features. The surface morphology for powdered Fe/V-HAP@PCL shows changes in grains size from 1.59–6.26 µm to 2.0–3.76 for the minimum and maximum Fe composition. The roughness average increased by increasing Fe substitution from 37.0 to 56.5 nm, while (Rq) rises from 49.8 to 73.7 nm. The surface morphology of nanofibers shows a diameter range from around 0.97–3.19 µm to 0.44–1.91 µm. Further, the roughness parameter of Ra rose from 34.96 to 59.49 nm. TEM micrographs revealed the diameters of nanofibrous scaffolds are around 200–360 nm. Mechanical parameters vary upon increasing dopant ions in HAP; tensile strength rises from 1.61 ± 0.8 to 4.93 ± 0.8 MPa. Moreover, the contact angle decreased by increasing Fe ion, in which values declined from 101.2 ± 2.5 to 85 ± 4.3°. Enhancing cell viability from 90.3 ± 3.1% to 97.5 ± 2.8% for the minimum and maximum Fe ions composition., The porosity of the nanofibrous surface improved, which illustrated increasing cell growth upon increasing dopant ion. Hence, modulating the nanofibrous scaffold by controlling the composition of doped metal ions could be advantageous for biomedical applications.