Abstract
Phytochemical and biological activity screening are the primary steps for isolation of new biologically active compounds, which lead to the discovery of new drugs. Calotropis procera (Ait). R. Br. (Asclepiadaceae) are widely used in traditional medicine to treat various diseases. To provide a scientific basis for traditional uses of Calotropis procera, the crude methanol extract of plant organs were investigated phytochemically. The plant contains various classes of bioactive secondary metabolites such as terpenoids, flavonoids, saponins, steroids and cardiac glycosides. The antimicrobial activities of the crude extracts of various plant organs were investigated too. The results were sufficiently positive to encourage further investigation.