Abstract
Exploring bioactive principles from seaweeds, one of the potential marine resources, draws atten-tion because of their wide array of pharmaceutical applications. In this study, the ethanol extract of the green macroalga Codium tomentosum was subjected to Gas Chromatography-Mass Spec-trometry analysis and was screened qualitatively for phytochemical composition. Further, the anti-inflammatory activity was evaluated by membrane stabilization assay and protease in-hibitory assay. Phytochemical analysis revealed the presence of tannins, flavonoids, phenol and alkaloids. Thirty bioactive principles were identified in the extract that includes tris (2,4-di-tert-butylphenyl) phosphate, hexadecanoic acid, methyl ester, octadecanoic acid, n-hexadecanoic acid etc. The extract of C. tomentosum exhibited significant anti-inflammatory activity. The results indicated that the phenolic compound tris (2,4-di-tert-butylphenyl) phosphate may be responsi-ble for the anti-inflammatory activity.