Abstract
Multidrug resistance (MDR) is one of the major global threats of this century. So new innovative approaches are needed for the development of existing antibiotics to limit antibacterial resistance. The current study was aimed to utilize extracts of root, stem, and leaves of Persicaria hydropiper for the synthesis of silver nanoparticles (AgNPs) using standard procedure. Synthesis of AgNPs was evident from the change in color of the solution to dark brownish and then it was further revealed by UV–Vis and Fourier Transformed Infrared Spectroscopy (FTIR). UV–Vis spectroscopy has revealed absorbance peak at 370 nm while, FTIR spectrum displayed that aromatics amines were used as reducing agent in the fabrication of AgNPs. In addition, Scanning Electron Microscopy (SEM micrograph) displaying tetrahedron, spherical and oval shapes of synthesized AgNPs whereas, average size of synthesized AgNPs was found in the range of 32–77 nm. Beside this, it was also observed that the potency of antibiotics against MDR bacteria increased after coating with synthesized AgNPs i.e., the potency of Ceftazidime and Ciprofloxacin increased up to 450% and 500% against Bacillus respectively while, the potency of Gentamicin, Vancomycin and Linezolid increased up to 150%, 200% and 58% against Bacillus, Staphylococcus, and Proteus species respectively. Furthermore, it was concluded that utilizing AgNPs in combination with commercially available antibiotics would provide an alternate therapy for the treatment of infectious diseases caused by MDR bacteria.