Abstract
A new triterpenic compound named pistagremic acid (PA) was once again isolated from Pistaciaintegerrima. The -secretase inhibition study was carried out. Compound PA was found significantly active against -secretase enzyme (BACE1) with IC50 value of 350 +/- 2nM in comparison to the standard inhibitors [Asn670, Sta671, Val672]-amyloid-/A4 precursor protein 770 fragment 662-675 (IC50=290.71 +/- 1nM). The selectivity of this compound was also evaluated against the acetylcholinesterase and butyrylcholinesterase enzymes. Interestingly compound PA was found to be inactive against them and showed selectivity towards -secretase enzyme (BACE1).