Abstract
Passive IgE-mediated anaphylaxis [i.v. injection of anti-IgE (EM95, 20μg)], passive oral antigen-induced IgE anaphylaxis [i.v. anti-trinitrophenyl (TNP)-IgE (20μg), followed by oral gavage with TNP-ovalbumin (TNP-OVA, 50mg)], and active oral antigen-induced anaphylaxis [i.p. 50μg OVA / 1mg alum followed by repeated oral gavage challenge of OVA (50mg)] were induced in BALB/c mice. [...]passive and active IgE-mediated oral antigen-induced shock (Temperature Change (oC) -2.98 ± 0.76 and -2.63 ± 0.47), were not associated with increased platelet activation compared to control groups (% positive CD62p ± SD; active oral: 33.4 ± 13.8 vs 17.2 ± 3.6, p = 0.1; passive oral: 12.8 ± 0.8 vs 15.1 ± 0.4, p = 0.017).