Abstract
A series of some fused and spiro heterocyclic compounds such as pyrazolines, Isoxazolines, pyrimidines, β -lactams, and thiazolidinone derivatives
3
,
6a-d
,
7a-d
,
9a-c
,
10a-c
,
11a-c
,
12a-c
,
13a-c
have been synthesised by cycloaddition and cycloconden-sation reaction of monochloroacetyl chloride, mercaptoacetic acid, hydrazines, hydroxylamine, urea, and thiourea incorporating the prepared compounds
5a-d
,
8a-c
. The synthesized compounds were tested for antibacterial and fungicidal activity. Gram-negative Bacillus cereus, Gram-negative serratia sp, as well as the fungus were used for this purpose. The biological assay was determined according to the filter paper disc method. Assay plates were incubated at 30°C one day for the bacteria and three dayes for the fungus (British Pharmacopoeia commisson, 1102m, London 1963). The test results show that the components have a strong and satisfactory effect.