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Poly(N-(2-hydroxypropyl)-methacrylamide)-valproic acid conjugates as block copolymer nanocarriers
Journal article   Peer reviewed

Poly(N-(2-hydroxypropyl)-methacrylamide)-valproic acid conjugates as block copolymer nanocarriers

Jawaher A. Alfurhood, Hao Sun, Christopher P. Kabb, Bryan S. Tucker, James H. Matthews, Hendrik Luesch and Brent S. Sumerlin
Polymer chemistry, Vol.8(34), pp.4983-4987
14/09/2017
DOI: https://doi.org/10.1039/c7py00196g
PMCID: PMC5612619
PMID: 28959359

Abstract

Physical Sciences Polymer Science Science & Technology
We report nanoassemblies based on block copolymers of N-(2-hydroxypropyl) methacrylamide (HPMA) in which drug cleavage enhances the biological compatibility of the original polymer carrier by regeneration of HPMA units. Drug release via ester hydrolysis suggests this approach offers potential for stimuli-responsive drug delivery under acidic conditions.

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