Abstract
Polyneuropathy, Organomegaly, Endocrinopathy, M Proteins, and Skin changes (POEMS) syndrome is a rare type of plasma cell dyscrasia. It is a paraneoplastic syndrome with multiple systemic manifestations. Diagnosis of POEMS syndrome is commonly challenging, due to its multisystemic involvement and its rarity. This case report described a 60 year old female patient who suffered from POEMS syndrome. The patient's symptoms were complicated. Initially, she was misdiagnosed as pulmonary tuberculosis. Subsequently, POEMS syndrome has been diagnosed based on clinical features and laboratory findings. After the diagnosis of POEMS syndrome, she treated with lenalidomide - dexamethasone regimen. The patient completed seven cycles with a significant response followed by a high dose of melphalan chemotherapy with autologous hematopoietic stem cell transplantation as consolidation therapy.