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Post-Translational Modification, Phase Separation, and Robust Gene Transcription
Journal article   Peer reviewed

Post-Translational Modification, Phase Separation, and Robust Gene Transcription

Hari R Singh and Yogesh B Ostwal
Trends in genetics, Vol.35(2), pp.89-92
02/2019
DOI: https://doi.org/10.1016/j.tig.2018.11.002
PMID: 30477958

Abstract

Chromatin - genetics Humans Phosphoric Monoester Hydrolases - genetics Phosphorylation Positive Transcriptional Elongation Factor B - genetics Protein Processing, Post-Translational - genetics RNA Polymerase II - genetics Transcription Factors - genetics Transcription, Genetic
A few recent reports reveal fundamental new insights into the intricate regulatory mechanisms that govern RNA polymerase II (Pol II)-mediated gene transcription. Whereas a histidine-rich domain (HRD) triggers phase separation, promoting transcription elongation, a phosphatase switch promotes transcription termination. A paradigm that might govern the underlying mechanisms leading to robust gene transcription is now starting to emerge.

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