Abstract
We report two cases of inflammatory reaction to postvaccination to Pfizer COVID-19 vaccine from Saudi Arabia: A case of delayed inflammatory reactions (DIRs) to hyaluronic acid (HA) dermal filler in the upper lip following the first dose of messenger ribonucleic acid Pfizer-BioNTech COVID-19 vaccine; the second case of DIR to HA filler underneath of eye following the second dose of Pfizer COVID-19 vaccine. The mechanism of this late reaction to HA fillers may be dependent on numerous factors and is not well understood.