Abstract
The purpose of the present study is to design of a safe drug consisting of vitamin D-3 and vanadyl (IV) ion as a novel complex for the treatment of diabetes. The new [(VD3)(VO)(OH)(H2O)(2)] vitamin D-3 vanadyl complex has been synthesized in alkaline media and well characterized. The speculated structural of vitamin D-3 vanadyl complex was discussed upon physicochemical techniques like micro-analytical, conductivity, spectroscopic (FT-IR and solid reflectance), magnetic measurement, thermogravimetric analyses (TG/TGA), and morphological (X-ray powder diffraction (XRD), scanning (SEM) and transmission (TEM) electron microscopes. The conductivity test was measured in dimethylsulfoxide solvent for both free vitamin D-3 (VD3) and its vanadyl (IV) complex that imply to an electrolyte behavior. The mathematical analysis and evaluation of kinetic parameters of the thermodynamic data (TG-DTG), such as entropy of activation, pre-exponential factor, activation energy evaluated by using Coats-Red fern and Horowitz-Metzger equation also were presented in this paper. The anti-diabetic efficiency and effectiveness of this complex was assessed against streptozotocin induced diabetic male albino rats. Overall, the current research illustrates a reliable, novel compound for the treatment of diabetes.