Abstract
Aim: Barbigerone is a natural pyranoisoflavone having antioxidant potential. The current research was aimed to study the anti-diabetic role of barbigerone on streptozotocin-induced experimental rats.
Material & methods: To perform the anti-diabetic activity, the animals were segregated into four groups: Group 1-Control (5 ml/kg saline), Group 2-Streptozotocin control (60 mg/kg i.p.), Group 3 and 4 - Barbigerone (10 and 20 mg/kg, respectively).
Results: Both the doses showed a beneficial effect on all the parameters assessed. The effect was better pronounced by 20 mg/kg than 10 mg/kg. Barbigerone showed a protective effect on blood glucose, lipid profile, antioxidant, liver enzymes, and inflammatory cytokines. It suggested that barbigerone displayed lipid-lowering action and antiperoxidative effect in streptozotocin-activated diabetic animals.
Conclusion: The outcome of this work reflects that 20 mg/kg barbigerone is more potent and produced ameliorative effects in streptozotocin-induced rats. (C) 2022 The Author. Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).