Abstract
Curcumin is naturally found in the dried rhizome of Curcuma longa plant and chemically it is polyphenol compound and has enormous biological applications such as antioxidant, anticancer, antibacterial, anti-Alzheimer's disease etc. In this study we investigated in-vitro antioxidant, anticancer and antibacterial potentials of the synthesized curcumin analogs (H1-H2) and have showed promising antioxidant activity by scavenging DPPH and ABTS free radicals at 1000 to 62.5 mu g/mL concentration. Compound (H1) showed anti-proliferative activity with IC50 254.16, 262.4 and 252.11 mu g/mL in 1000 to 62.6 mu g/mL concentration, while curcumin (H2) showed comparable anti-proliferative activity with IC50 of 477.8, 254.8 and 462.6 mu g/mL against 3 T3, HeLa and MCF-7 cell lines respectively. Antibacterial activity showed that Proteus mirabilis, Escherichia coli, Staphylococcus aureus and Bacillus cereus were significantly susceptible towards both synthesized curcumin analogs (H1-H2). It was concluded from this study that the synthesized compounds could be helpful in the treatment of cancer and bacterial infection by further exploring their pharmacological profile.