Abstract
1.
1. The climbing behaviour in mice was used for studying possible interaction(s) of d-LSD with dopamine receptors.
2.
2. Doses of d-LSD ranging from 0,25 to 2,5 mg/kg injected intra-peritoneally constantly inhibited the climbing behaviour.
3.
3. In contrast, when similar doses of d-LSD were injected 10 min before apomorphine (5 mg/kg), a constant potentiation of the apomorphine-induced climbing was observed.
4.
4. Subsequent experiments performed with a neuroleptic (haloperidol) or a serotonin precursor (5-OH-tryptophan) compared to those of d-LSD with and without apomorphine would indicate that d-LSD alone displays typical serotoninergic syndrome (including inhibition of the climbing), whereas in the presence of apomorphine, an interaction at presynaptic receptors may possibly modulate dopaminergic activity.