Abstract
Glutathione-S-transferase is a major phase-II detoxification enzyme in parasitic helminthes. Previous research highlights the
importance of GSTs in the establishment of chronic infections in cytotoxic microenvironments. Filarial nematodes depend on these
detoxification enzymes for their survival in the host. GST plays an important role in filariasis and other diseases. GST from
W.bancrofti
and
B.malayi
are very much different from human GST. This structural difference makes GST potential
chemotherapeutic targets for antifilarial treatment. In this study we have checked the efficacy of some well known antifilarial
compounds against GST from
B.malayi
and
W.bancrofti
. The structure of
BmGST
was modeled using modeller9v10 and was
submitted to PMDB. Molecular docking study reveals arbindazole to be the most potent compounds against GST from both the
filarial parasites. Role of some residues playing important role in the binding of compounds within the active site of GST has also
been revealed in the present study. The
BmGST
and
WbGST
structural information and docking studies could aid in screening new
antifilarials or selective inhibitors for chemotherapy against filariasis.