Abstract
Collecting evidence suggests that the intercellular infection of
Chlamydia pneumoniae
in lungs contributes to the etiology of lung cancer. Many proteins of
Chlamydia pneumoniae
outmanoeuvre the various system of the host. The infection may regulate various factors, which can influence the growth of lung cancer in affected persons. In this
in-silico
study, we predict potential targeting of
Chlamydia pneumoniae
proteins in mitochondrial and cytoplasmic comportments of host cell and their possible involvement in growth and development of lung cancer. Various cellular activities are controlled in mitochondria and cytoplasm, where the localization of
Chlamydia pneumoniae
proteins may alter the normal functioning of host cells. The rationale of this study is to find out and explain the connection between
Chlamydia pneumoniae
infection and lung cancer. A sum of 183 and 513 proteins were predicted to target in mitochondria and cytoplasm of host cell out of total 1112 proteins of
Chlamydia pneumoniae
. In particular, many targeted proteins may interfere with normal growth behaviour of host cells, thereby altering the decision of program cell death. Present article provides a potential connection of
Chlamydia pneumoniae
protein targeting and proposed that various targeted proteins may play crucial role in lung cancer etiology through diverse mechanisms.