Abstract
Differential scanning calorimetry was used as a screening technique for the investigation of the physicochemical compatibility of diclofenac sodium and mebeverine hydrochloride with a number of commonly used tablet excipients and polymers. Diclofenac sodium was found to exhibit interactions with povidone (PVP), stearic acid, polyethylene glycol 6000, sodium cyclamate, polyacrylate-polymethacrylate copolymers, hydroxypropyl methylcellulose and carbomer 934, while it was found to be compatible with tricalcium phosphate, methylcellulose, starch, microcrystalline cellulose, titanium dioxide and polycarbophil. Mebeverine hydrochloride was found to interact only with PVP and stearic acid, while it was compatible with the other excipients and polymers used.