Abstract
A new six intraperitoneal injection insulin-mimetic vanadyl (II) compounds [(VD3-1) (VO+2) (AA(n)(-1))] (where (n= 1 similar to 6) ; AA(1) =isoleucine, AA(2) =threonine, AA(3) =proline, AA(4) =phenylalanine, AA(5) =lysine and AA(6) =glutamine) were synthesized by the chemical reactions between vitamin D-3 (VD3) VOSO4 and amino acids (AA(n)) with equal molar ratio 1 : 1 : 1 in neutralized media. The structures of these complexes were elucidated by spectroscopic methods like, infrared and solid reflectance spectroscopes. Magnetic moments and electronic spectra reveal square pyramid geometrical structure of the complexes. The infrared spectra assignments of these complexes revealed that the chelation towards vanadyl (IV) ions existed via deprotonation of the hydroxyl group of VD3 drug ligand and so amino acids act as bidentate ligand via N-amino and O-carboxylate groups. The anti-diabetic efficiency of these complexes were evaluated against streptozotocin induced diabetic male albino rats.