Abstract
Several hydrophilic and hydrophobic polymeric materials, namely, hydroxypropyl methylcellulose (Methocel K4M, K15M, and K100M), hydroxypropylcellulose (HPC-JXF & GXF), hydroxyethylcellulose (HEC), and Kollidon SR were evaluated as tablet matrix materials for sustaining/controlling the release of Ketoprofen. All the formulations were prepared by direct compression method. The dissolution profiles were compared to that of the marketed preparation Apo-Keto SR(R) tablet. Similarity factor (F2), values in between test formulation and marketed preparation was calculated to choose the best formulation. The release kinetics from various matrices was also studied. Increase in the polymer content reduced the rate of drug release. At the same polymer content in the matrix, the drug release was most sustained with tablets prepared using HPMC (K4M) followed by HPC-GXF, Kollidon SR, HEC and HPC-JXF. A comparison of different grades of HPMC and HPC showed that the drug release was more sustained with higher molecular weight. Out of all the formulations studied matrix tablets containing 20% of HPC-GXF showed comparable dissolution profile to the marketed preparation as indicated by a similarity factor value of (F2) 77.98%. The release of drug from marketed preparation and matrix with HPC-GXF 20% was found to be a combination of both diffusion and erosion (anomalous) as per korsmeyer-peppas equation.