Abstract
The anodic voltammetric behavior of amiloride hydrochloride (AmilCl) was studied at carbon paste electrode in 0.04 M Britton-Robinson buffer pH 2.96 using cyclic and differential pulse voltammetric techniques. Cyclic voltammetric study indicates that the oxidation process is irreversible and controlled by adsorption. Parameters affecting on the oxidation of AmilCl are optimized. Under the optimal conditions the oxidation peak current is proportional to concentration of AmilCl in the range 0.60-4.23 mu g/ml AmilCl with detection and quantitation limits of 0.26 and 0.87 mu g/ml AmilCl, respectively. The proposed method was successfully applied for the assay of AmilCl in Moduretic tablets.