Abstract
Compounds
2
and
9
were formed using 3-(4-chloro-phenyl)-1-pyridin-2-yl propenone (
1
) and malononitrile or ethyl cyanoacetate, respectively. The pyridine derivative
2
was in turn used as a precursor for the preparation of some pyridopyrimidine and fused pyridopyrimidine derivatives
3-8
On the other hand, the pyridine derivative
9
was used for the preparation of thienopyridine derivatives
11
and
12
Nitrozation of compound
12
afforded pyridothienotriazine derivative
13
Some of the prepared products showed potent antimicrobial activity.