Abstract
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•Letrozole dispersed HEMA polymerization onto acrylamide grafted LDPE (AAm-g-LDPE) sheet.•Cross-link pHEMA hydrogel coating for controlled release of poorly soluble, letrozole, in SUF medium.•In vitro releases results optimized 72% drug released at the end of 72 h measurement.•The best correlation for the release profile of letrozole obtained in Higuchi and Korsmeyer–Peppas kinetics models.•The 98.37% cell viability revealed the biocompatibility of the system, good for in vivo curing of endometriosis.
This paper focuses on the development of a drug delivery system for systemically controlled release of a poorly soluble drug, letrozole. The work meticulously describes the preparation and characterizations of 2-hydroxyethyl methacrylate (HEMA) polymerization onto hydrophilic acrylamide grafted low-density polyethylene (AAm-g-LDPE) surface for targeted drug release system. The surface morphology and thickness measurement of coated pHEMA layer were measured using scanning electron microscopy (SEM). The swelling study was done in deionized (DI) water and simulated uterine fluid (SUF, pH = 7.6). In vitro release of letrozole from the system was performed in SUF. Further, the release kinetics of letrozole from the system was studied using different mathematical models. The results, suggest that the rate of drug release can be altered by varying the concentrations of cross-linker in pHEMA. The optimized sample released 72% drug at the end of 72 h of measurement.