Abstract
A wide variety of β-aminoesters are prepared in good yields by the reaction of lithium ester enolates derived from ketene silyl acetals with N-(alkylamino)benzotriazoles. The secondary β-aminoesters readily cyclize to β-lactams (2-azetidinones) on deprotonation.
A wide variety of β-aminoesters are prepared by the reaction of lithium ester enolates with the readily available adducts from an aldehyde or ketone, an amine and benzotriazole. Secondary β-aminoesters are converted to the corresponding β-lactams.