Abstract
A new series of metal complexes of Ti(IV), V(IV), Y(III), Zr(IV), Ce(IV) and U(VI) with levofloxacin (Levo) were synthesized and characterized by elemental analysis, molar conductivity, magnetic moment measurements, UV-Vis, FT-IR and H-1 NMR, XRD as well as TG-DTG techniques. The data indicated that levofloxacin reacts as a bidentate ligand chelate to the metal ion through the pyridone oxygen and one carboxylato oxygen. The thermal dehydration and decomposition of the complexes were studied kinetically using Coats-Redfern and Horowitz-Metzger methods, and the thermodynamic data reflected the thermal stability for all complexes. The calculated bond length and the bond stretching force constant, F(U=O), values for UO2 bond are 1.86 and 690.67 N m(-1). The biological activities of the levofloxacin, meta-salts and their metal complexes were assayed against different bacterial and fungal species as well as their effect on degradation of calf thymus DNA.