Abstract
A total of 300 gastric biopsy samples and 50
Helicobacter pylori
isolates were collected from Ethiopian adult dyspeptic patients. The
vacA
and
cagA
genes were detected in 90 and 79% of biopsy specimens, respectively, and in 100 and 87% of clinical isolates, respectively. Both genes were detected in 84% of the gastric biopsy samples and in 87% of the clinical isolates. Among
vacA
genotypes, the s1/m1 genotype was the most common in gastric biopsy samples (48%). The
vacA
and
cagA
positive
H. pylori
strains were detected to a higher degree in patients with chronic active gastritis (71%) than patients with other histopathological findings (29%) (
P
< 0.05).