Abstract
Background Patients with sickle cell disease (SCD), which is an inherited autosomal recessive disorder, experience a broad range of symptoms and complications such as acute chest syndrome, infections, strokes, seizures, etc. The main objective of this study was to assess the prevalence of depressive symptoms among SCD patients and determine the impact of sociodemographic factors and genotypes on depressive symptoms in Makkah City, Saudi Arabia. Methods A cross-sectional study was conducted among SCD patients aged 18 and above in the outpatient clinics in Makkah's four main hospitals (Al Noor Specialist Hospital, King Faisal Hospital, King Abdulaziz Hospital, and Hera General Hospital) from December 2021 to April 2022. A total of 222 patients used a self -administrative questionnaire with an Arabic version of Patient Health Questionnaire-9 (PHQ-9) to assess for depression. Data were analyzed using IBM SPSS Statistics, version 26, and the chi-square (chi 2) test was applied to examine the relationship between the variables. A p-value of less than 0.05 was regarded as statistically significant. Results The overall prevalence of depression was 85.6%, and multivariate analysis showed that age between 18 and 30 had a significant statistical value for the prevalence of depression (p-value = 0.029). Univariate analysis also indicated that low levels of education (p-value = 0.037) and low monthly income (p-value = 0.017) had a significant association with depression prevalence. Conclusion There is a high prevalence of depression among SCD patients in the Makkah region. Therefore, we recommend establishing a regular regional screening program and psychiatry referral for this patient population.