Abstract
Angiosarcomas are aggressive and highly malignant tumors of endothelial cells, occurring mainly in the skin or superficial soft tissue of the head, neck and the breast. Primary angiosarcoma of the small intestine is extremely rare and very few cases have been reported in literature. We herein describe a case of primary duodenal epithelioid angiosarcoma with metastasis to the abdominal lymph nodes, lumbar vertebra, sacrum and iliac crest, in a 63-year-old gentleman. On initial evaluation, the clinical findings appeared suspicious of multiple myeloma. The patient was subsequently diagnosed as duodenal angiosarcoma based on radiology, endoscopy, histopathology and immunohistochemistry findings. Awareness of this aggressive and rapidly progressive entity is important. Due to its rarity, its clinical presentation can be misinterpreted at the outset, as it was in our case, leading to delayed diagnosis and management. To the best of our knowledge, this is the first report of primary angiosarcoma of the small intestine from the Middle East.