Abstract
A new cyclic depsipeptide (1) has been isolated from culture broth of Staphylococcus sp. (No. P-100826-4-6) derived from Corallina officinalis L., together with the known compounds indol-3-carboxylic acid (2), 1,5-dideoxy-3-C-methyl arabinitol (3), thymine (4), uracil (5), cyclo (L-pro-L-omet) (6) and macrolactin B (7). The structure of (1) was established to be cyclo (2 alpha, 3-diaminopropoinc acid-L-Asn-3-beta-hydroxy-5-methyl-tetradecanoic acid-L-Leu(1)-L-Asp-L-Val-L-Leu(2)-L-Leu(3)) by extensive spectroscopic techniques including H-1 NMR, C-13 NMR, H-1-H-1 COSY, HMBC, HSQC, NOESY, and HRFABMS. The antimicrobial activities of compounds 1-7 were evaluated. Compounds 1-5, and 7 showed moderate antimicrobial activity while compound 6 exhibited a potent antimicrobial and antifungal activities.