Abstract
The growth of activated human T lymphocytes in response to interleukin-2 (IL-2) is suppressed by transforming growth factor-beta (TGF- beta ). This study presents data that show a diminished response of two human lymphoma cell lines to physiologic regulation by TGF- beta . Cell line L-428 was derived from the malignant pleural effusion of a patient with far advanced nodular sclerosing Hodgkin's disease and has been shown to have clonal gene rearrangements characteristic of both B and T lymphocytes. The Ki-1 lymphomas derived from activated lymphocytes appear to secrete TGF- beta activity but continue to proliferate because of defective suppression of IL-2 (and related lymphokine)-dependent DNA synthesis.